tag:blogger.com,1999:blog-8211371452778645597.post8967311970268296851..comments2023-07-15T04:39:59.759-07:00Comments on Genomics, Medicine, and Pseudoscience: Chronic fatigue syndrome researcher arrestedSteven Salzberghttp://www.blogger.com/profile/16549957293973146438noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-8211371452778645597.post-53271449777748212882011-11-21T22:33:16.946-08:002011-11-21T22:33:16.946-08:00@Salzberg, did you know the retraction of Silverma...@Salzberg, did you know the retraction of Silvermans data proves the other studies have optimised to the wrong viruses? The viruses in people with ME are HGRVs not VP62/XMRV or the prostate cancer xenotropic MRVs.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8211371452778645597.post-37067906978346915552011-11-21T21:25:32.256-08:002011-11-21T21:25:32.256-08:00Lipkin cannot now be consudered a neutral as he is...Lipkin cannot now be consudered a neutral as he is investigating CFS separately and the reasons for the multi lab study have been answered. The negative papers have been looking for the wrong viruses using clinically unvalidated assays. What we have is gag sequences that are polytropic, the same finding Lo et al made. Only when the isolates from Lombardi et al are fully sequenced will we know what host range those viruses are, but some will likely be another type of xenotropic, which is the largest host range for MLVs.<br /><br />There is no issue with Frank Ruscettis western blots as Science and Coffin the reviewer saw all the original data in 2009 and they asked for the label change.<br /><br />As for missing materials, it is only alleged that they are stolen and Mikovits could not have had the opportunity to take them. Moreover people who are hostile toward Mikovits/Ruscetti's discovery have been posting what is said to be the original raw gel from the Lombardi data since the 4th October.<br /><br />Trine as a food writer is best left to the chefs.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8211371452778645597.post-23317047627054682942011-11-21T12:44:09.950-08:002011-11-21T12:44:09.950-08:00I follow Trine Tsouderos work and have heard her s...I follow Trine Tsouderos work and have heard her speak. She is absolutely the very best science writer/reporter working for a newspaper that I have come across and she completely outshines the hacks at the NYT. Thanks for the link as I don't take the paper or live in Chicago. I usually see her work through other skeptic writers.<br /><br />One of my woo-inclined friends is bound to bring this topic up, so thanks for giving me some good debunking material.Janet Camphttps://www.blogger.com/profile/03645361065385918800noreply@blogger.comtag:blogger.com,1999:blog-8211371452778645597.post-68185019491474853282011-11-21T07:43:27.770-08:002011-11-21T07:43:27.770-08:00"Mistaken Hypothesis" ? You go too far.
..."Mistaken Hypothesis" ? You go too far.<br />All efforts to reproduce the original findings have been thwarted by the fact that the presumed template sequence (VP62) was in fact a contaminant.<br />That doesn't make it a mistaken hypothesis.<br />Error strewn reports such as this, unfortunately push open-minded opinion in the wrong direction and are not supported by the facts or evidence.Paul Wattonnoreply@blogger.comtag:blogger.com,1999:blog-8211371452778645597.post-16427113851338767842011-11-21T07:27:53.566-08:002011-11-21T07:27:53.566-08:00I suspect Ian Lipkin will make substantial inroads...I suspect Ian Lipkin will make substantial inroads into a search for the cause of ME/CFS, at least in subgroups, with his large, cutting edge metagenomics project that is underway. <br /><br />The one thing this project funded by the Hutchins Family Foundation through the Chronic Fatigue Initiative has in common with Lombardi et al is that patient selection will be narrowly defined using both a research definition and a clinical definition. <br /><br />Contamination isn't the only variable worth noting. Mixing in people without a disease into a study of patients who do have a disease is also a recipe for disaster. And practically speaking, conclusions based on tiny cohorts are difficult to extrapolate - particularly if multiple pathogens are involved for example. The scientific literature on CFS is littered with such examples. <br /><br />As for Lipkin's other study on XMRV, we can pretty much guess what the answer will be. <br /><br />P.S. <br /><br />Technically only the NCI lab under Robert Silverman stated that they had introduced contamination into the process through their cell line. <br /><br />As for falsification of data, post doc Abbie Smith aka ERV had a reader point out that the same slides had been relabeled to make very different points. Trine reported this.<br /><br />Dr. Frank Ruscetti has stated that the presentation where the altered captions were shown was rushed and a simple error was made. No idea if that is the truth or not - it's not improbable and since none of us were there nor have ESP it's hard for us to do more than speculate. <br /><br />Was it falsification of data in the actual paper? There is no such indication at this time.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8211371452778645597.post-73552208870837078232011-11-21T06:08:27.426-08:002011-11-21T06:08:27.426-08:00The key question is what JM's allegedly stolen...The key question is what JM's allegedly stolen data actually is and what it tells us about the paper. It would be very unfortunate if the legal case against JM meant that this data wasn't made available to scientists until the case is concluded.Neuroskeptichttp://neuroskeptic.blogspot.comnoreply@blogger.com